Evaluation of lumpy skin disease virus, a capripoxvirus, as a replication-deficient vaccine vector
نویسندگان
چکیده
منابع مشابه
Evaluation of Humoral and Cell-mediated Immunity of Two Capripoxvirus Vaccine Strains against Lumpy Skin Disease Virus
Background and Aims: Prevention of Lumpy skin disease (LSD) in cattle is heavily dependent on vaccination. Since the genetic structure of LSD virus has the close relatedness with other Capri-pox virus (CaPV). Therefore, the use of vaccine strains of CaPV derived from sheep and goat would be useful to protect cattle against LSD. Materials and Methods: The susceptible calves of dairy farms were ...
متن کاملGenome of lumpy skin disease virus.
Lumpy skin disease virus (LSDV), a member of the capripoxvirus genus of the Poxviridae, is the etiologic agent of an important disease of cattle in Africa. Here we report the genomic sequence of LSDV. The 151-kbp LSDV genome consists of a central coding region bounded by identical 2.4 kbp-inverted terminal repeats and contains 156 putative genes. Comparison of LSDV with chordopoxviruses of othe...
متن کاملEarly and late transcriptional phases in the replication of lumpy-skin-disease virus.
Approximately 71 of the estimated 145 kilobase pairs of the genome of the South African isolate of lumpy-skin-disease virus, Neethling strain, was cloned into the plasmid vector pBluescribe. Selected clones were used in Northern blot analysis to investigate the replication cycle of the virus. The synthesis of early mRNA was initiated immediately after infection, and continued for approximately ...
متن کاملLumpy Skin Disease
Lumpy skin disease is a poxviral disease with significant morbidity in cattle. Although the mortality rate is generally low, economic losses result from loss of condition, decreased milk production, abortions, infertility and damaged hides. The causative virus seems to be spread mainly by insects, and outbreaks can be widespread and difficult to control. Lumpy skin disease was confined to Afric...
متن کاملLumpy Skin Disease
Lumpy skin disease (LSD, knopvelsiekte) is a pox disease of cattle characterised by fever, nodules 4 on the skin, mucous membranes and internal organs, emaciation, enlarged lymph nodes, oedema 5 of the skin, and sometimes death. The disease is of economic importance because it causes 6 reduced production, particularly in dairy herds. It also causes damage to the hide. LSD is caused by 7 strains...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2003
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.19116-0